The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.
Nadine BachtlerSandra TorresCristina OrtizRobert SchierwagenOlaf TycChristoph HieberMarie-Luise BerresCaroline MeierNico KrausStefan ZeuzemBart NijmeijerSebas PronkJonel TrebickaSabine KleinPublished in: PloS one (2023)
ROCK inhibition by the tested compounds decreased contraction but increased migration. Y-33075 proved more potent than Y27632 in the inhibition of contraction of HSCs and should be further evaluated in chronic liver disease.