The Anti-Nociceptive Effects of Nicotine in Humans: A Systematic Review and Meta-Analysis.
Yujia LuoYating YangCarl Richard SchneiderThomas BallePublished in: Pharmaceuticals (Basel, Switzerland) (2023)
These results help to clarify the mixed outcomes of trials and may ultimately inform the treatment of pain. We observed that acute nicotine administration prolonged the laboratory-induced pain threshold and tolerance time and may mildly relieve postoperative pain. In addition, long-term tobacco smoking may have a nociceptive effect on different types of chronic pain. More research is needed to determine the anti-nociceptive effects of nicotine in humans, and to understand the optimal timing, dose, and method of delivery of nicotine.
Keyphrases
- chronic pain
- smoking cessation
- neuropathic pain
- postoperative pain
- pain management
- replacement therapy
- spinal cord
- spinal cord injury
- drug induced
- liver failure
- high glucose
- type diabetes
- diabetic rats
- oxidative stress
- endothelial cells
- metabolic syndrome
- combination therapy
- skeletal muscle
- insulin resistance
- acute respiratory distress syndrome