Construction of the 2-Amino-1,3-selenazole Skeleton via PhICl 2 /KSeCN-Mediated Selenocyanation/Cyclization.

The construction of 2-amino-1,3-selenazole skeleton was realized via the PhICl 2 /KSeCN-enabled electrophilic selenocyanation of β-enaminones and β-enamino esters followed by intramolecular cyclization under basic conditions. Compared to the classical Hantzsch strategy that utilizes selenourea or its analogues as starting materials or crucial intermediates, this method might represent an alternative approach for the assembly of 1,3-selenazole framework through a different pathway.