Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis.

Xiaoyan WeiJulia FrankeMario OstKristina WardelmannStefan BörnoBernd TimmermannDavid Meierhofer André Kleinridders Susanne Klaus Sigmar Stricker

Published in: Journal of cachexia, sarcopenia and muscle (2020)

Our results demonstrate a cell autonomous role for Nf1 in myogenic cells during postnatal muscle growth required for metabolic and proteostatic homeostasis. Furthermore, Nf1 deficiency in muscle drives cross-tissue communication and mobilization of lipid reserves.

Keyphrases

skeletal muscle
signaling pathway
lps induced
induced apoptosis
single cell
pi k akt
oxidative stress
preterm infants
nuclear factor
cell therapy
stem cells
mesenchymal stem cells
cell proliferation
cell death