Competitive Endogenous RNA (ceRNA) Regulation Network of lncRNA-miRNA-mRNA in Colorectal Carcinogenesis.

Jingwei LiuHao LiBowen ZhengLiping SunYuan YuanChengzhong Xing

Published in: Digestive diseases and sciences (2019)

We identified significantly altered lncRNAs, miRNAs and mRNAs in colorectal carcinogenesis, which might serve as potential biomarkers for tumorigenesis of CRC. In addition, the ceRNA regulatory network of lncRNA-miRNA-mRNA was constructed, which would elucidate novel molecular mechanisms involved in initiation and progression of CRC, thus providing promising clues for clinical diagnosis and therapy.

Keyphrases

long non coding rna
network analysis
binding protein
long noncoding rna
transcription factor
wastewater treatment
genome wide analysis
stem cells
bone marrow