Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers.

Varsha SinghPayal MandalShweta Singh ChauhanIshrat Jahan Saifinull MarhabaP V SandeepPankaj JagdaleAnjaneya AyanurKausar Mahmood Ansari

Published in: Toxicology research (2024)

Our finding conclude that ZEA targets the uterus and cause inflammation due to increased levels of inflammatory cytokines and proliferation mediators, as well as systemic toxicity denoted by a strong binding affinity with serum proteins.

Keyphrases

oxidative stress
high fat diet induced
signaling pathway
endometrial cancer
drug induced
binding protein
mass spectrometry
skeletal muscle
metabolic syndrome
transcription factor
oxide nanoparticles