Xanthones from Securidaca inappendiculata antagonized the antirheumatic effects of methotrexate in vivo by promoting its secretion into urine.

Dan-Dan WangYan LiYi-Jin WuYi-Lai WuJun HanOpeyemi Joshua OlatunjiLi WangJian Zuo

Published in: Expert opinion on drug metabolism & toxicology (2020)

It is suggested that the combined use of S. inappendulata with MTX should be optimized to avoid the antagonistic effects and improve the safety of the MTX regimen.

Keyphrases

rheumatoid arthritis
high dose
low dose