Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis.
Emilie CoppinXinyi ZhangLee OhayonEbin JohnyAnkush DasariKang H ZhengLotte StiekemaEugenia Cifuentes-PaganoPatrick J PaganoSrilakshmi ChaparalaErik S StroesPartha DuttaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Our findings demonstrate increased inflammation, HSPC abundance in the vascular niches of the bone marrow, and elevated IL-3Rb and IL-1R1 (IL-1 receptor 1) expression in HSPC following HI. Furthermore, the IL-3Rb and IL-1R1 signaling plays a pivotal role in HSPC proliferation, leukocyte abundance, and atherosclerosis aggravation after HI.