Pandoraea sp infection in a lung transplant patient and the critical role of MALDI-TOF in accurate bacterial identification.
Catherine-Audrey BoutinGilbert CornutVéronica Bilik PintoSimon Grandjean LapierrePublished in: Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada (2020)
Diagnosis and clinical management of pulmonary infections in lung transplant patients are challenging. The increased diversity of bacterial species identified from clinical samples with novel proteomics-based systems can further complicate clinical decision making in this highly vulnerable population. Whether newly recognized organisms are colonizers or true pathogens often remains controversial since symptoms causality and impact on lung function is often unknown. We present the case of a 48-year-old female lung transplant patient with Pandoraea sp infection. We review and discuss the role of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for accurate bacterial identification. We report on therapeutic management and clinical outcome.
Keyphrases
- mass spectrometry
- lung function
- end stage renal disease
- case report
- high resolution
- cystic fibrosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- chronic obstructive pulmonary disease
- air pollution
- pulmonary hypertension
- prognostic factors
- gram negative
- peritoneal dialysis
- ms ms
- bioinformatics analysis
- emergency department
- patient reported
- drug induced