The mechanosensitive ion channel TRPV4 is a regulator of lung development and pulmonary vasculature stabilization.

Joshua T MorganWade G StewartRobert A McKeeJason P Gleghorn

Published in: Cellular and molecular bioengineering (2018)

These studies have identified TRPV4 as a potential mechanosensor involved in transducing mechanical forces on the airways to molecular and transcriptional events that regulate the morphogenesis of the three essential tissue compartments in the lung.

Keyphrases

transcription factor
neuropathic pain
pulmonary hypertension
cystic fibrosis
gene expression
case control
single molecule
heat shock
oxidative stress
risk assessment