TRIMming TGF-β signals in Th17 cells.
Aaron S RapaportWenjun OuyangPublished in: The Journal of experimental medicine (2018)
The precise downstream mediators of TGF-β signaling in Th17 and T reg cells remain unclear. In this issue of JEM, Tanaka et al. report that Trim33 transduces TGF-β signals in Th17 cells to generate an optimal proinflammatory cytokine profile.