TRIMming TGF-β signals in Th17 cells.

Published in: The Journal of experimental medicine (2018)

The precise downstream mediators of TGF-β signaling in Th17 and T reg cells remain unclear. In this issue of JEM, Tanaka et al. report that Trim33 transduces TGF-β signals in Th17 cells to generate an optimal proinflammatory cytokine profile.

Keyphrases

induced apoptosis
cell cycle arrest
transforming growth factor
signaling pathway
oxidative stress
cell proliferation