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TRIMming TGF-β signals in Th17 cells.

Aaron S RapaportWenjun Ouyang
Published in: The Journal of experimental medicine (2018)
The precise downstream mediators of TGF-β signaling in Th17 and T reg cells remain unclear. In this issue of JEM, Tanaka et al. report that Trim33 transduces TGF-β signals in Th17 cells to generate an optimal proinflammatory cytokine profile.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • transforming growth factor
  • signaling pathway
  • oxidative stress
  • cell proliferation