Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis.
Yongchang LiErliang KongRuifeng DingRuitong ChuJinfang LuMengqiu DengTong HuaMei YangHaowei WangDashuang ChenHonghao SongHuawei WeiPing ZhangChaofeng HanHong-Bin YuanPublished in: CNS neuroscience & therapeutics (2024)
Hyperglycemia induces metabolic reprogramming and inflammatory activation in microglia through the regulation of Sirt3 transcription and degradation. This novel mechanism identifies Sirt3 as a potential drug target for treating DNP.
Keyphrases
- neuropathic pain
- oxidative stress
- diabetic rats
- spinal cord
- spinal cord injury
- ischemia reperfusion injury
- type diabetes
- inflammatory response
- cell proliferation
- drug induced
- high glucose
- signaling pathway
- wound healing
- gene expression
- climate change
- risk assessment
- lipopolysaccharide induced
- endothelial cells
- electronic health record