δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis.

Fabrizio FontanaMonica MarzagalliMichela RaimondiValentina ZucoNadia ZaffaroniPatrizia Limonta

Published in: Cell proliferation (2021)

δ-TT triggers G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis in OC cells and sensitizes them to platinum treatment, thus representing an interesting option for novel chemopreventive/therapeutic strategies for OC.

Keyphrases

cell cycle arrest
pi k akt
cell death
induced apoptosis
signaling pathway
oxidative stress
dna damage
cell proliferation
endoplasmic reticulum stress
reactive oxygen species
combination therapy