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Single-cell RNA sequencing for the study of kidney disease.

Jiayi ZhuJinrong LuHuachun Weng
Published in: Molecular medicine (Cambridge, Mass.) (2023)
The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (scRNA-seq) in nephrology has developed rapidly. In this review, we summarized the technical platform related to scRNA-seq and the role of this technology in investigating the onset and development of kidney diseases, starting from several common kidney diseases (mainly including lupus nephritis, renal cell carcinoma, diabetic nephropathy and acute kidney injury), and provide a reference for the application of scRNA-seq in the study of kidney disease diagnosis, treatment and prognosis.
Keyphrases
  • single cell
  • rna seq
  • high throughput
  • acute kidney injury
  • diabetic nephropathy
  • renal cell carcinoma
  • gene expression
  • mesenchymal stem cells
  • dna methylation
  • smoking cessation