Pharmacokinetic modeling and simulation support for age- and weight-adjusted dosing of dabigatran etexilate in children with venous thromboembolism.

Daniel RöshammarFenglei HuangManuela AlbisettiLisa BomgaarsElizabeth ChalmersMatteo LucianiJacqueline HaltonLesley G MitchellMartin BergstrandMoustafa M A IbrahimDavid JosephIgor TartakovskySavion GropperMartina BrueckmannLeonardo Rodrigues Brandão

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Using a population PK model of DE for children with VTE, simulations showed that the final dosing algorithms were appropriate for all DE formulations; no dose titration was needed.

Keyphrases

venous thromboembolism
young adults
direct oral anticoagulants
machine learning
atrial fibrillation
physical activity
deep learning
molecular dynamics