Mass Cytometry of CSF Identifies an MS-Associated B-cell Population.

David JohanssonCéline RauldJulien RouxCamille RegairazEdoardo GalliIlaria CallegariLayla RaadAnnick WaldtRachel CuttatGuglielmo RomaMartin DieboldBurkhard BecherJens KuhleTobias DerfussJosé M CarballidoNicholas S R Sanderson

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

When analyzed without a priori assumptions, both the soluble and the cellular compartments of the CSF in MS were characterized by markers related to B cells, and the strongest candidate for an MS-specific cell type has a B-cell phenotype.

Keyphrases

mass spectrometry
multiple sclerosis
ms ms
single cell
genome wide
cerebrospinal fluid
drug induced