Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA 2 Prostanoids/TP Axis.

Jiahui GeYingbi ZhouHui LiRuhui ZengKaiqi Xie Jing LengXijian ChenGang YuXinya ShiYineng XuDong HePi GuoYongyin ZhouHongjun LuoWenhong LuoBin Liu

Published in: Circulation research (2024)

prostanoids/TP axis plays an essential role in mediating the augmentation of EDC and cardiovascular disorders when PGIS is deficient, suggesting TP as a promising therapeutic target in diseases associated with PGIS insufficiency.

Keyphrases

chronic obstructive pulmonary disease
nitric oxide
risk assessment
smooth muscle
soft tissue
replacement therapy
pulmonary hypertension