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Modulation of the Endocannabinoid System Following Central Nervous System Injury.

Juan ZhouHaneen NooriIan BurkovskiyJ Daniel LafreniereMelanie E M KellyChristian Lehmann
Published in: International journal of molecular sciences (2019)
Central nervous system (CNS) injury, such as stroke or trauma, is known to increase susceptibility to various infections that adversely affect patient outcomes (CNS injury-induced immunodepression-CIDS). The endocannabinoid system (ECS) has been shown to have immunoregulatory properties. Therefore, the ECS might represent a druggable target to overcome CIDS. Evidence suggests that cannabinoid type 2 receptor (CB₂R) activation can be protective during the early pro-inflammatory phase after CNS injury, as it limits neuro-inflammation and, therefore, attenuates CIDS severity. In the later phase post CNS injury, CB₂R inhibition is suggested as a promising pharmacologic strategy to restore immune function in order to prevent infection.
Keyphrases
  • blood brain barrier
  • oxidative stress
  • atrial fibrillation
  • cerebrospinal fluid
  • binding protein