Lopinavir/ritonavir treatment increases the placental transfer of bupivacaine enantiomers in human immunodeficiency virus-infected pregnant women.

Rodrigo Metzker Pereira RibeiroFernanda de Lima Moreira Elaine Christine Dantas Moisés Ricardo de Carvalho Cavalli Silvana Maria Quintana Vera Lucia Lanchote Geraldo Duarte

Published in: British journal of clinical pharmacology (2018)

This study supports that the placental transfer of both bupivacaine enantiomers was 100% higher in HIV-pregnant women treated with lopinavir/ritonavir when compared with that in healthy pregnant women receiving epidural anaesthesia for caesarean section.

Keyphrases

pregnant women
human immunodeficiency virus
antiretroviral therapy
hiv infected
hiv positive
hepatitis c virus
hiv aids
pain management
pregnancy outcomes
spinal cord
capillary electrophoresis
mass spectrometry
south africa