Clearance Profile of Circulating Tumor Human Papillomavirus DNA During Radiotherapy Predicts Clinical Outcomes in Human Papillomavirus-Related Oropharyngeal Cancer.

Hidenori Tanaka Atsuhiko Uno Yukinori TakenakaMotoyuki SuzukiYuji Seo Norihiko TakemotoTakahito FukusumiHirotaka EguchiHaruka KanaiMasafumi HorieFumiaki IsohashiKazuhiko OgawaHirotsugu Shiroma Hidenori Inohara

Published in: JCO precision oncology (2023)

In patients with HPV16-related oropharyngeal squamous cell carcinoma receiving radiotherapy, a slow ctHPV16DNA clearance profile could prelude unfavorable outcomes. Monitoring ctHPV16DNA is essential for determining the clearance profile, which might help optimize treatment intensity individually.

Keyphrases

circulating tumor
cell free
circulating tumor cells
squamous cell carcinoma
locally advanced
early stage
radiation therapy
radiation induced
single molecule
high intensity
metabolic syndrome
young adults
nucleic acid
insulin resistance
skeletal muscle
smoking cessation