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Enantioselective Palladium-Catalyzed Cross-Coupling of α-Bromo Carboxamides and Aryl Boronic Acids.

Bowen LiTiejun LiMuinat A AliyuZhen Hua LiWenjun Tang
Published in: Angewandte Chemie (International ed. in English) (2019)
We herein report an enantioselective palladium-catalyzed cross-coupling between α-bromo carboxamides and aryl boronic acids, generating a series of chiral α-aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asymmetric palladium-catalyzed coupling of α-bromo carbonyl compounds.
Keyphrases
  • capillary electrophoresis
  • ionic liquid
  • solid state