In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist.

Ben JonesVinod BuradeElina AkalestouYusman ManchandaZenouska RamchunderGaëlle CarratMarie-Sophie Nguyen-TuPiero MarchettiLorenzo PiemontiIsabelle LeclercRajamannar ThennatiTina VilsbollBernard ThorensAlejandra TomasGuy A Rutter

Published in: Diabetes, obesity & metabolism (2022)

GL0034 is a G protein-biased agonist that shows powerful antidiabetic effects in mice, and may serve as a promising new GLP-1RA for obese patients with type 2 diabetes.

Keyphrases

adipose tissue
rheumatoid arthritis
metabolic syndrome
weight loss
high fat diet induced
disease activity
obese patients
ankylosing spondylitis
systemic lupus erythematosus
insulin resistance