Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways.

Sen RenJing ChenDominik DuscherYutian LiuGuojun GuoYu KangHewei XiongPeng ZhanYang WangCheng WangHans-Günther MachensZhenbing Chen

Published in: Stem cell research & therapy (2019)

Our data suggest that ASC-MVs can stimulate HUVEC, HaCAT, and fibroblast functions. ASC-MV therapy significantly accelerates wound healing, and the benefits of ASC-MVs may due to the involvement of AKT and ERK signaling pathways. This illustrates the therapeutic potential of ASC-MVs which may become a novel treatment paradigm for cutaneous wound healing.

Keyphrases

signaling pathway
wound healing
nlrp inflammasome
pi k akt
stem cells
induced apoptosis
epithelial mesenchymal transition
cell proliferation
endothelial cells
adipose tissue
electronic health record
big data
metabolic syndrome
combination therapy
deep learning
replacement therapy
smoking cessation