Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis.
Roberta MagliozziSimon HametnerFrancesco FacchianoDamiano MarastoniStefania RossiMarco CastellaroAlberto PoliFederico LattanziAndrea ViscontiRichard St John NicholasRichard ReynoldsSalvatore MonacoHans LassmannMassimiliano CalabresePublished in: Annals of clinical and translational neurology (2019)
Intrathecal dysregulation of iron homeostasis and coagulation pathway as well as B-cell and monocyte activity are strictly correlated with cortical damage at early disease stages.