mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus.

Tomas PetrasekIveta VojtechovaOndrej KlovrzaKlara TuckovaCestmir VejmolaJakub RakAnna SulakovaDaniel KapingNadine BernhardtPetrus J de VriesJakub OtahalRobert Waltereit

Published in: Journal of neurodevelopmental disorders (2021)

These findings may contribute to an explanation why ASD symptoms in individuals with TSC, where comorbid early-onset epilepsy is common, were not reliably ameliorated by mTOR inhibitors in clinical studies.

Keyphrases

early onset
late onset
cell proliferation
autism spectrum disorder
attention deficit hyperactivity disorder
intellectual disability
depressive symptoms