Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain.
Jose R RobadorManuel J FeinauerStefan W SchneiderFrank T MayerChristian GorzelannyArtur SacharowXiaobo LiuAnna BerghoffMaria A BrehmDaniela HirschJulia StadlerSabine Vidal-Y-SiEwa WladykowskiMarisse AsongKai NowakMarcel Seiz-RosenhagenViktor UmanskyChristian MessKlaus PantelFrank WinklerAlexander T BauerPublished in: Neuro-oncology advances (2021)
Our data indicate that platelet-derived VWF is involved in cerebral clot formation and in metastatic growth of melanoma in the brain. Targeting platelet activation with low-molecular-weight heparins represents a promising therapeutic approach to prevent melanoma BM.