A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11.

Vered Stearns Opeyemi A Jagede Victor Tsu-Shih Chang Todd C Skaar Jeffrey L Berenberg Ranveer Nand Atif Shafqat Nisha Lassi Jacobs William Luginbuhl Paul Gilman Al Bowen Benson Judie R Goodman Gary L Buchschacher Norah L Henry Charles L Loprinzi Patrick J Flynn Edith P Mitchell Michael Jordan Fisch Joseph A Sparano Lynne I Wagner

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We were unable to prospectively validate candidate SNPs previously associated with AI discontinuation due to AIMSS. Future analyses will explore additional genetic markers, patient-reported outcome predictors of AIMSS, and differences by race.

Keyphrases

patient reported outcomes
genome wide
copy number
dna methylation
current status
gene expression
physical activity