Puberty is a critical window for the impact of diet on mammary gland development in the rabbit.

Cathy Hue-BeauvaisJohann LaubierNicolas BrunInès HoutiaFlorence JaffrezicClaudia BevilacquaFabienne Le ProvostMadia Charlier

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2019)

Taken together, our results demonstrate that the consumption for 5 weeks of an obesogenic diet during the pubertal period initiates mammary structure modifications and affects mammary epithelial cell proliferation and differentiation. Our findings highlight the potentially important role played by unbalanced nutrition during critical early-life windows in terms of regulating mammary epithelial cell differentiation and subsequent function in adulthood.

Keyphrases

early life
physical activity
cell proliferation
weight loss
depressive symptoms
cell cycle
signaling pathway
gestational age