Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma.
Jaime Gállego Pérez-LarrayaMarc Garcia-MoureSara LabianoAna Patiño-GarcíaJessica DobbsMarisol Gonzalez-HuarrizMarta ZalacainLucia MarrodanNaiara Martinez-VelezMontserrat PuigdellosesVirginia LaspideaItziar AstigarragaBlanca Lopez-IborOfelia CruzMiren Oscoz LizarbeSandra Hervas-StubbsGorka Alkorta-AranburuIbon TamayoBeatriz TaviraRuben Hernandez-AlcocebaChris JonesGitanjali DharmadhikariCristian Ruiz-MorenoHenk StunnenbergEsther HullemanJasper van der LugtMiguel A IdoateRicardo Diez-ValleInés Esparragosa VázquezMaria VillalbaCarlos de AndreaJorge M Núñez-CórdobaBrett EwaldJoan RobbinsJuan FueyoCandelaria Gomez-ManzanoFrederick F LangSonia TejadaMarta Marija AlonsoPublished in: The New England journal of medicine (2022)
Intratumoral infusion of oncolytic virus DNX-2401 followed by radiotherapy in pediatric patients with DIPG resulted in changes in T-cell activity and a reduction in or stabilization of tumor size in some patients but was associated with adverse events. (Funded by the European Research Council under the European Union's Horizon 2020 Research and Innovation Program and others; EudraCT number, 2016-001577-33; ClinicalTrials.gov number, NCT03178032.).