The Impact of KRAS Mutation on the Presentation and Prognosis of Non-Metastatic Colon Cancer: an Analysis from the National Cancer Database.

Aaron ScottPaolo GoffredoTimothy GinaderJennifer HrabeIrena Gribovskaja-RuppMuneera R KapadiaRonald J WeigelImran Hassan

Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2020)

KRAS-mutated colon cancers were more frequently observed in black patients, right-sided locations, and higher-stage tumors. These mutations had a negative prognostic impact for stage III patients, suggesting that the incorporation of genotypic data into colon cancer staging may help to guide systemic therapy and prognostication of colon cancer patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
squamous cell carcinoma
small cell lung cancer
lymph node
stem cells
machine learning
emergency department
young adults
mesenchymal stem cells
patient reported
big data