High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer.
Minyu WangYu-Kuan HuangJoseph Ch KongYu SunDaniela G TantaloHan Xian Aw YeangLe YingFeng YanDakang XuHeloise HalseNatasha Di CostanzoIan R GordonCatherine MitchellLaura K MackayRita A BusuttilPaul Joseph NeesonAlex BoussioutasPublished in: Clinical & translational immunology (2020)
These novel findings identify the combination of CD8+ T cells and FOXP3+CD4+ T cells as a significant prognostic marker for GC patients, which also could potentially be targeted and applied in the combination therapy with immune checkpoint blockades in precision medicine.