Lipopolysaccharides increase the risk of colorectal cancer recurrence and metastasis due to the induction of neutrophil extracellular traps after curative resection.
Wei-Wei WangLipei WuWenying LuWei ChenWenhui YanChunrun QiShihai XuanAnquan ShangPublished in: Journal of cancer research and clinical oncology (2021)
These findings shed light on the mechanism underlying the relationship between the elevated rate of colorectal cancer recurrence in patients who underwent surgery and the incidence of infection. This mechanism involves the protumorigenic activities of LPS-induced formation of NETs. The NETs which could be mediated by the TLR9 and the mitogen-activated protein kinase signaling pathway.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- end stage renal disease
- prognostic factors
- newly diagnosed
- ejection fraction
- chronic kidney disease
- minimally invasive
- toll like receptor
- peritoneal dialysis
- risk factors
- immune response
- free survival
- rectal cancer
- pi k akt
- epithelial mesenchymal transition
- tyrosine kinase
- cell proliferation
- surgical site infection