A Performance Comparison of Commonly Used Assays to Detect RET Fusions.
Soo-Ryum YangUmut AyparEzra Y RosenDouglas A MataRyma BenayedKerry MullaneyGowtham JayakumaranYanming ZhangDenise FrosinaAlexander E DrilonMarc LadanyiAchim A JungbluthNatasha RekhtmanJaclyn F HechtmanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Although DNA sequencing has high sensitivity and specificity, RNA sequencing of RET SVUS is necessary. Both FISH and IHC demonstrated lower sensitivity for NCOA4-RET fusions.