WEE1 kinase inhibitor MK-1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status.

Aisha Hussein Al-JamaeiJan G A M de VisscherV Ramadugula SubramanyamTymour ForouzanfarPeter SminiaBehrouz Zandieh DoulabiMarco N Helder

Published in: Oral diseases (2022)

These results demonstrate the efficacy of MK-1775 in enhancing the radiation effect on OTSCC in vitro associated with a significant apoptotic death rate, identifying WEE1 inhibitor as a potent radiosensitizer in OTSCC irrespective of p53 mutational status.

Keyphrases

squamous cell
cell death
anti inflammatory
radiation induced
induced apoptosis
oxidative stress
signaling pathway