Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1.
Diede WitkampEllen OudejansGino V Hu-A-NgLeoni HoogterpAleksandra M KrzywańskaMilo ŽnidaršičKevin MarinusChristina F de Veij MestdaghImke BartelinkMarianna BugianiMarjo S van der KnaapTruus E M AbbinkPublished in: Annals of clinical and translational neurology (2022)
Guanabenz proved itself as a viable treatment option for VWM. The exact mechanism through which guanabenz exerts its ameliorating impact on VWM requires further studies. Sephin1 is not simply a guanabenz replacement without α2-adrenergic effects.