d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?

Dina Medina-Vera Juan Antonio Navarro Patricia RiveraCristina Rosell-ValleAlfonso Gutiérrez-AdánCarlos SanjuanAntonio Jesús López-GamberoRubén TovarJuan Suarez Francisco Javier Pavón Elena BaixerasJuan DecaraFernando Rodríguez de Fonseca

Published in: British journal of pharmacology (2022)

The present findings suggest that d-pinitol, by regulating CDK5 activity through a decrease of CDK5R1, is a potential drug for developing treatments for neurological disorders such as tauopathies.

Keyphrases

cell cycle
human health
cell proliferation
emergency department
tyrosine kinase
signaling pathway
climate change
blood brain barrier
drug induced