Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts.

Ryoji KatoKoji HarataniHidetoshi HayashiKazuko SakaiHitomi SakaiHiasto KawakamiKaoru TanakaMasayuki TakedaKimio Yonesaka Kazuto NishioKazuhiko Nakagawa

Published in: British journal of cancer (2020)

Our results suggest that nintedanib targeted CAFs and thereby attenuated the immunosuppressive nature of the TME and promoted the intratumoural accumulation and activation of CD8+ T cells, with these effects contributing to enhanced antitumour activity in combination with ICB.

Keyphrases

idiopathic pulmonary fibrosis
interstitial lung disease
cancer therapy
extracellular matrix
rheumatoid arthritis
adipose tissue
high fat diet induced
metabolic syndrome
skeletal muscle
systemic sclerosis
risk assessment
climate change