Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.

Mukundan AtturHua ZhouJohathan SamuelsSvetlana KrasnokutskyMichelle YauJose U ScherMichael DohertyAnthony G WilsonJenny BencardinoMarc HochbergJoanne M JordanBraxton MitchellVirginia B KrausSteven B Abramson

Published in: Annals of the rheumatic diseases (2019)

Carriage of the IL1RN TTG haplotype is associated with more severe rOA, increased risk for incident OA, and increased evidence of inflammation in RA. These data suggest that the IL1RN TTG risk haplotype, associated with decreased IL-1Ra plasma levels, impairs endogenous 'anti-inflammatory' mechanisms.

Keyphrases

knee osteoarthritis
rheumatoid arthritis
cardiovascular disease
anti inflammatory
copy number
oxidative stress
disease activity
type diabetes
ankylosing spondylitis
systemic lupus erythematosus