HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription.
Long XuHaixia XieShan HuXiaoduo ZhaoMengke HanQiaojuan LiuPinning FengWeidong WangChunling LiPublished in: Acta physiologica (Oxford, England) (2022)
HDAC inhibitors prevented the downregulation of AQP2 induced by potassium deprivation, probably by enhancing H3K27 acetylation.