One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides.
Xiangmin LiShanchao WuShuqiang ChenZengwei LaiHai-Bin LuoChunquan ShengPublished in: Organic letters (2018)
A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D2O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange, and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.