Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice.
Mohamed A GhoneimMahmoud M GabrAyman F RefaieSawsan M El-HalawaniMohga M Al-IssawiBatoul L ElbassiounyMai A Abd El KaderAmani M IsmailMona F ZidanMary S KarrasRaghda W MagarSherry M KhaterSylvia A AshamallahMahmoud M ZakariaMalgorzata KlocPublished in: Stem cell research & therapy (2022)
Transplantation of IPCs derived from allogenic hAT-MSCs into humanized mice was followed by a muted allogenic immune response that did not interfere with the functionality of the engrafted cells. Our findings suggest that such allogenic cells could offer an opportunity for cell therapy for insulin-dependent diabetes without immunosuppression, encapsulation or gene manipulations.
Keyphrases
- induced apoptosis
- stem cells
- type diabetes
- cell cycle arrest
- immune response
- cardiovascular disease
- bone marrow
- endothelial cells
- glycemic control
- endoplasmic reticulum stress
- cell death
- mesenchymal stem cells
- gene expression
- single cell
- signaling pathway
- oxidative stress
- metabolic syndrome
- genome wide
- cell proliferation
- copy number
- dendritic cells
- dna methylation
- pi k akt