Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke.
Joonsang YooJeong-Ho HongSeong-Joon LeeYong-Won KimJi Man HongChang-Hyun KimJin Wook ChoiDong-Hun KangYong-Sun KimYang Ha HwangJin Soo LeeSung Il SohnPublished in: Journal of clinical medicine (2020)
Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. We compared the characteristics of patients with and without AKI and independent factors associated with AKI after EVT. We also investigated the effects of AKI on functional outcomes and mortality at 3 months. Of the 601 patients analyzed, 59 patients (9.8%) developed AKI and five patients (0.8%) started renal replacement therapy after EVT. In the multivariate analysis, diabetes mellitus (odds ratio (OR), 2.341; 95% CI, 1.283-4.269; p = 0.005), the contrast agent dose (OR, 1.107 per 10 mL; 95% CI, 1.032-1.187; p = 0.004), and unsuccessful reperfusion (OR, 1.909; 95% CI, 1.019-3.520; p = 0.040) were independently associated with AKI. The presence of AKI was associated with a poor functional outcome (OR, 5.145; 95% CI, 2.177-13.850; p < 0.001) and mortality (OR, 8.164; 95% CI, 4.046-16.709; p < 0.001) at 3 months. AKI may also affect the outcomes of ischemic stroke patients undergoing EVT. When implementing EVT, practitioners should be aware of these risk factors.
Keyphrases
- acute kidney injury
- cardiac surgery
- acute ischemic stroke
- end stage renal disease
- endovascular treatment
- risk factors
- ejection fraction
- newly diagnosed
- patients undergoing
- chronic kidney disease
- magnetic resonance
- prognostic factors
- primary care
- heart failure
- magnetic resonance imaging
- metabolic syndrome
- computed tomography
- adipose tissue
- cardiovascular disease
- acute coronary syndrome
- percutaneous coronary intervention
- insulin resistance
- single molecule
- contrast enhanced
- glycemic control
- mass spectrometry
- data analysis