Photo- and Tetrazine-Responsive Modulation of trans -Zeatin.

Photoirradiation and small organic molecule triggering of appropriately designed caged hormones enable the control and manipulation of the corresponding biological processes with high spatial and temporal resolution. Caged trans -zeatin substituted with nitrobenzene carbonates as photoremovable protecting groups and trans -cyclooctene as the tetrazine-responsive motif have been synthesized. A smooth release of the trapped trans -zeatin molecule has been achieved, permitting targeted perturbation of biological processes, including degradation, glucosylation, and recognition by appropriate enzymes.