The effect of acute topiramate administration on morphine withdrawal syndrome and brain-derived neurotrophic factor in central nervous system.
Songül ÖzkulaMahluga Jafarova DemirkapuHasan Raci YananlıBanu AydinCevdet NacarHülya CabadakPublished in: Neurological research (2023)
The findings of this study indicate that topiramate administered into the lateral ventricle and nucleus accumbens reduces naloxone-induced morphine withdrawal symptoms, stereotypical locomotor activity, and changes the BDNF/proBDNF ratio.
Keyphrases
- drug induced
- liver failure
- spinal cord injury
- pulmonary hypertension
- high glucose
- pulmonary artery
- diabetic rats
- respiratory failure
- case report
- cerebrospinal fluid
- aortic dissection
- atrial fibrillation
- endothelial cells
- left ventricular
- oxidative stress
- coronary artery
- stress induced
- hepatitis b virus
- physical activity
- intensive care unit
- congenital heart disease