Spatially Informed Gene Signatures for Response to Immunotherapy in Melanoma.
Thazin Nwe AungJonathan WarrellSandra Martinez-MorillaNiki GavrielatouIoannis A VathiotisVesal YaghoobiHarriet M KlugerMark B GersteinDavid L RimmPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
We conclude that the spatially defined compartment signatures utilize tumor and tumor microenvironment-specific information, leading to more accurate prediction of treatment outcome, and thus merit prospective clinical assessment.