MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion.
Saravanakumar MarimuthuImayavaramban LakshmananSakthivel MuniyanShailendra K GautamRama Krishna NimmakayalaSatyanarayana RachaganiPranita AtriAshu ShahNamita BhyravbhatlaKavita MallyaPaul M GrandgenettMichael A HollingsworthKaustubh DattaManeesh JainMoorthy P PonnusamySurinder Kumar BatraPublished in: Molecular cancer research : MCR (2022)
This study shows that MUC16 plays a critical role in PDAC liver metastasis by mediating NRP2 regulation by JAK2/STAT1 axis, thereby paving the way for future therapy efforts for metastatic PDAC.