Emerging Role of Neutrophil Extracellular Traps in Gastrointestinal Tumors: A Narrative Review.
Yujun ZhangJingjing SongYiwei ZhangTing LiJie PengHaonan ZhouZhen ZongPublished in: International journal of molecular sciences (2022)
Neutrophil extracellular traps (NETs) are extracellular fibrous networks consisting of depolymerized chromatin DNA skeletons with a variety of antimicrobial proteins. They are secreted by activated neutrophils and play key roles in host defense and immune responses. Gastrointestinal (GI) malignancies are globally known for their high mortality and morbidity. Increasing research suggests that NETs contribute to the progression and metastasis of digestive tract tumors, among them gastric, colon, liver, and pancreatic cancers. This article explores the formation of NETs and reviews the role that NETs play in the gastrointestinal oncologic microenvironment, tumor proliferation and metastasis, tumor-related thrombosis, and surgical stress. At the same time, we analyze the qualitative and quantitative detection methods of NETs in recent years and found that NETs are specific markers of coronavirus disease 2019 (COVID-19). Then, we explore the possibility of NET inhibitors for the treatment of digestive tract tumor diseases to provide a new, efficient, and safe solution for the future therapy of gastrointestinal tumors.
Keyphrases
- coronavirus disease
- immune response
- sars cov
- gene expression
- stem cells
- staphylococcus aureus
- systematic review
- prostate cancer
- dna damage
- type diabetes
- dna methylation
- genome wide
- dendritic cells
- risk factors
- toll like receptor
- inflammatory response
- coronary artery disease
- rectal cancer
- high resolution
- quantum dots
- cell therapy
- minimally invasive
- mass spectrometry
- stress induced
- meta analyses