Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration.

Marta SansYihui ChenFredrik I ThegeRongzhang DouJimin MinMichele Yip-SchneiderJianjun ZhangRanran WuEhsan IrajizadYuki MakinoKimal I RajapaksheMark W HurdRicardo A León-LetelierJody VykoukalJennifer B DennisonKim-Anh DoRobert A WolffPaola A GuerreroMichael P KimC Max SchmidtAnirban MaitraSamir HanashJohannes F Fahrmann

Published in: bioRxiv : the preprint server for biology (2023)

Enhanced sulfatide metabolism is an early metabolic alteration in cystic pre-cancerous lesions of the pancreas that persists through invasive neoplasia. Targeting sulfatide biosynthesis might represent an actionable vulnerability for cancer interception.

Keyphrases

papillary thyroid
cell wall
single cell
climate change
high grade
genome wide
cancer therapy
dna methylation