Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus.
Huanyu ZhouJin YangChetan SrinathAliya ZengIris WuElena C LeonTawny Neal QureshiChristopher A ReidEmily R NettesheimEmma XuZoe DuclosTamer M A MohamedFarshad FarshidfarAnthony FejesJun LiuSamantha JonesCharles FeathersTae Won ChungFrank JingWilliam S PrinceJianMin LinPengzhi YuDeepak SrivastavaTimothy HoeyKathryn N IveyLaura M LombardiPublished in: Circulation (2023)
Collectively, these results advance the application of cardiac reprogramming gene therapy as a viable therapeutic approach to treat chronic heart failure resulting from ischemic injury.