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Cardiovascular diseases may play a negative role in the prognosis of amyotrophic lateral sclerosis.

Jessica MandrioliL FerriA FasanoE ZucchiN FiniC MogliaC LunettaK MarinouN TicozziG Drago FerranteC ScialoG SorarùF TrojsiA ConteY M FalzoneR TortelliM RussoV A SansoneG MoraV SilaniP VolantiC CaponnettoG QuerinM R MonsurròM SabatelliA ChiòN RivaG LogroscinoS MessinaA Calvo
Published in: European journal of neurology (2018)
Our large, multicentre study demonstrated that, together with the known clinical factors that are known to be prognostic for ALS survival, hypertension and heart diseases (i.e. atrial fibrillation and heart failure) as well as haematological diseases are independently associated with a shorter survival. Our findings suggest some mechanisms that are possibly involved in disease progression, giving new interesting clues that may be of value for clinical practice and ALS comorbidity management.
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